Table 2 Serotonin (SERT) and dopamine (DAT) transporter binding potential (BPND) changes in patients with social anxiety disorder (SAD) after treatment with SSRI + ICBT or placebo + ICBT.
x | y | z | Z | PFWE | Cluster volume1 | |
|---|---|---|---|---|---|---|
Serotonin transporter (SERT) | ||||||
SSRI + ICBT | ||||||
Occupancy | ||||||
All regions | Inf | |||||
Placebo + ICBT | ||||||
Increase BPND | ||||||
Raphe | −4 | −30 | −28 | 3.31 | 0.009 | 632 |
Dopamine (DAT) | ||||||
SSRI + ICBT | ||||||
Increase | ||||||
L Amygdala | −28 | 4 | −18 | 3.41 | 0.008 | 752 |
R Amygdala | 18 | 0 | −18 | 3.59 | 0.005 | 1432 |
L Hippocampus | −36 | −18 | −14 | 3.92 | 0.006 | 376 |
R Hippocampus | 30 | −28 | −6 | 3.36 | 0.035 | 24 |
L NAcc | −12 | 12 | −12 | 3.27 | 0.005 | 264 |
R NAcc | 12 | 12 | −12 | 3.09 | 0.007 | 168 |
L Putamen | −24 | 12 | −10 | 3.44 | 0.026 | 328 |
Placebo + ICBT | ||||||
Increase | ||||||
L Amygdala | −24 | 4 | −18 | 3.58 | 0.006 | 968 |
R Amygdala | 20 | 6 | −18 | 4.04 | 0.002 | 1440 |
L Hippocampus | −20 | −20 | −14 | 3.36 | 0.040 | 16 |
R Hippocampus | 28 | −16 | −22 | 4.43 | 0.001 | 568 |
L NAcc | −12 | 10 | −14 | 3.71 | 0.001 | 224 |
R NAcc | 12 | 12 | −12 | 3.04 | 0.009 | 56 |
L Putamen | −16 | 16 | −10 | 3.28 | 0.046 | 16 |
R Putamen | 30 | 12 | −8 | 3.86 | 0.009 | 504 |
