Fig. 4: Effects of miR-132-5p agomir on depression-like phenotype. | Translational Psychiatry

Fig. 4: Effects of miR-132-5p agomir on depression-like phenotype.

From: A key role of miR-132-5p in the prefrontal cortex for persistent prophylactic actions of (R)-ketamine in mice

Fig. 4

A Treatment schedule. AgomiR-132-5p (200 nmol, 2 μl/day) or agomiR-NC (control: 2 μl/day) was administered i.c.v. to mice for 3 days (day 1–day 3). Locomotion test (LMT), forced swimming test (FST) and sucrose preference test (SPT) were performed after the final injection of agomiR-NC or agomiR-132-5p (day 4 and day 5). The prefrontal cortex (PFC) was collected after SPT. B Body weight change (two-way repeated measures ANOVA: F2,36 = 3.765, P = 0.033). C Locomotion test (unpaired Student t-test: P = 0.129). D FST (unpaired Student t-test: P = 0.034). E SPT (unpaired Student t-test: P = 0.012). F Expression of miR-132-5p in the PFC (unpaired Student t-test: P = 0.033). G Bdnf mRNA in the PFC (unpaired Student t-test: P = 0.0005). (H): Tgfb1 mRNA in the PFC (unpaired Student t-test: P = 0.018). The data represent mean ± SEM (n = 10). *P < 0.05, **P < 0.01, ***P < 0.001. N.S., not significant.

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