Table 1 Description of the studies included to the analyses.

BPA2

R01MH076971

PI: Phillips

Toward the Identification of Biomarkers of Bipolar Disorder. This completed project examined biological markers of BD type-I that reflect pathophysiologic brain processes common to depression and remission and specific to bipolar disorder.

Dx: BD, UD, HC

Scanner: 3T Siemens Trio at the MRRC at the University of Pittsburgh

Acquisition parameters: MPRAGE: voxel = 1 mm³, TR = 2200 ms, 192 slices. EPI: voxel = 3.2 mm³, TR = 2000 ms, 39 slices

18–45

COBY

R01MH059929

MPIs: Birmaher, Phillips, Versace

Course and Outcome of Bipolar Disorder in Youth. This ongoing project aims to determine how previous clinical course of BD and treatment exposure from childhood into adulthood impacts neural circuitry functioning and structure in individuals with BD.

Dx: BD, HC

Scanner: 3 T Siemens PRISMA at the MRRC at the University of Pittsburgh

Acquisition parameters: MPRAGE: voxel = 1 mm³, TR = 1520 ms, 176 slices. EPI: MB = 3, voxel = 2.3 mm³, TR = 1500 ms, 54 slices

18–35

DIAMOND

R01MH100041

PI: Phillips

Reward, Pathophysiologic Dimensions and Psychological Distress in Young Adults. This ongoing project aims to identify relationships among functioning in working memory and other neural circuitry and various dimensions of psychopathology in young individuals seeking help for psychological distress.

Dx: BD, UD, HC

Scanner: 3 T Siemens Trio or PRISMA at the MRRC at the University of Pittsburgh

Acquisition parameters: MPRAGE: voxel = 1 mm³, TR = 2200 ms, 192 slices. EPI on PRISMA: MB = 3, voxel = 2.3 mm³, TR = 1500 ms, 54 slices. EPI on TRIO: voxel = 3.2 mm³, TR = 2000 ms, 39 slices

18–25