Fig. 3: The expression of GR after chronic morphine treatment and its role on miR-105 expression. | Translational Psychiatry

Fig. 3: The expression of GR after chronic morphine treatment and its role on miR-105 expression.

From: Two kinds of transcription factors mediate chronic morphine-induced decrease in miR-105 in medial prefrontal cortex of rats

Fig. 3

a GR mRNA level in rat mPFC in morphine and saline groups (n = 6 in each group, two-tailed t-test, *P = 0.0442). b GR protein level in rat mPFC in morphine and saline groups (n = 3 in each group, two-tailed t-test, *P = 0.0419). c The levels of miR-105 of primary cultured mPFC neurons treated by chronic morphine and LV-NC-RNAi or LV-GR-RNAi (n = 6 in each group, two-way ANOVA, F(1,20) = 11.43, P = 0.003. Bonferroni’s post-tests: ***P < 0.0001, t = 8.270, saline+ LV-GR-RNAi group vs saline+ LV-NC-RNAi group; ###P < 0.0001, t = 13.050, morphine + LV-GR-RNAi group vs morphine + LV-NC-RNAi group). d The miR-105 levels in rat mPFC of morphine+ LV-GR-RNAi group and morphine + LV-NC-RNAi group (n = 3 in each group, unpaired two-tailed Student’s t-test, t = 6.185, **P = 0.0035). Data are presented as mean ± SEM.

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