Fig. 4: The role of ERK-p90RSK-CREB signaling pathway in GR expression increase induced by chronic morphine treatment in primary cultured neurons. | Translational Psychiatry

Fig. 4: The role of ERK-p90RSK-CREB signaling pathway in GR expression increase induced by chronic morphine treatment in primary cultured neurons.

From: Two kinds of transcription factors mediate chronic morphine-induced decrease in miR-105 in medial prefrontal cortex of rats

Fig. 4

a The levels of GR protein expression in primary cultured mPFC neurons of each group (n = 3 in each group, one-way ANOVA, F(3,8) = 107.7, P = 0.000, Bonferroni post hoc: **P = 0.031, Morphine group vs Control group ##P = 0.000, Mor+U0126 group and Mor+LJI308 group vs Morphine group). b The level of p-CREB in primary cultured mPFC neurons of each group (n = 3 in each group, one-way ANOVA, F(3,8) = 16.37, P = 0.009, Bonferroni post hoc: **P = 0.002, Mor+LV-NC-RNAi group vs LV-NC-RNAi group; #P = 0.032, Mor+LV-GR-RNAi group vs LV-GR-RNAi group; P = 0.097, Mor+LV-NC-RNAi group and Mor+LV-GR-RNAi group). Data are presented as mean ± SEM.

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