Fig. 5: Effect of GR expression induced by chronic morphine treatment on the retrieval of contextual morphine withdrawal memory. | Translational Psychiatry

Fig. 5: Effect of GR expression induced by chronic morphine treatment on the retrieval of contextual morphine withdrawal memory.

From: Two kinds of transcription factors mediate chronic morphine-induced decrease in miR-105 in medial prefrontal cortex of rats

Fig. 5

a Experimental timeline for the CPA procedure. b Left: Diagram of virus injection site in mPFC. Right: Image of coronal brain slice showing the expression of LV virus in mPFC. Scale bar, 500 μm. c Average pre-test and post-test CPA scores in Morphine + LV-NC-RNAi and Morphine + LV-GR-RNAi group (two-way ANOVA, virus treatment factor, F(1,38) = 9.996, P = 0.0031; test condition factor, F(1,38) = 35.56, P < 0.0001; virus treatment x condition, F(1,38) = 7.594, P = 0.0089; Bonferroni post hoc analysis). The post-test CPA scores in Morphine + LV-GR-RNAi was significantly lower than that of the morphine + LV-NC-RNAi group (two-way ANOVA, Bonferroni post hoc analysis, t = 4.184, ***P = 0.0003). Data are presented as mean ± SEM.

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