Fig. 7: TREM2 regulates the arginase 1+ microglial phenotype and is associated with the BDNF-TrkB signaling pathway. | Translational Psychiatry

Fig. 7: TREM2 regulates the arginase 1+ microglial phenotype and is associated with the BDNF-TrkB signaling pathway.

From: Nrf2 regulates the arginase 1+ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice

Fig. 7

A–C Western blot assay showing BDNF, PSD-95, and the ratio of p-TrkB/TrkB expression in the mPFC. The data are presented as the means ± SEMs (n = 5 or 6). *P < 0.05, **P < 0.01, and ***P < 0.001 (one-way ANOVA). D Representative photomicrographs and quantification of the dendritic spine density in the mPFC. Scale bar = 10 μm. The data are presented as the means ± SEMs (n = 5). *P < 0.05 and ***P < 0.001 (one-way ANOVA). E The working model for Nrf2-induced TREM2 transcription in the model of depression. Activation of Nrf2 by SFN induces an arginase 1+ microglial phenotype by initiating TREM2 transcription and thus ameliorates depression-like behavior in mice.

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