Fig. 3: Adjusted trajectories of general cognitive function for the APOE haplotype groups. | Translational Psychiatry

Fig. 3: Adjusted trajectories of general cognitive function for the APOE haplotype groups.

From: The APOE locus is linked to decline in general cognitive function: 20-years follow-up in the Doetinchem Cohort Study

Fig. 3

This figure shows the adjusted trajectories of general cognitive function for three APOE groups (i.e. ɛ2 carriers, ɛ3 homozygotes and ɛ4 carriers) up to 20-years follow-up (n = 2559). T0-T20 represents time in years. The trajectories were adjusted for sex, age at baseline, and population stratification using the first two gPCs. In addition, we included time (0–20 years with 5-year intervals, i.e. five time points) into the model, and the interaction terms SNP*time and age at baseline*time.

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