Table 2 Adjusted HRs for the association between continuous relative amplitude and brain disorder incidents.

From: Association of circadian rhythms with brain disorder incidents: a prospective cohort study of 72242 participants

  

Model 1

Model 2

 

Events

HR (95% CI)

p-value

HR (95% CI)

p-value

All-cause dementia

262

1.22 (1.14–1.29)

<0.001

1.23 (1.15–1.31)

<0.001

 Alzheimer’s disease

115

1.12 (0.98–1.28)

0.102

1.16 (1.01–1.33)

0.036*

Parkinson’s disease

190

1.28 (1.22–1.35)

<0.001

1.33 (1.25–1.41)

<0.001

Stroke

481

1.14 (1.07–1.22)

<0.001

1.13 (1.06–1.22)

<0.001

Depression

1102

1.23 (1.18–1.27)

<0.001

1.18 (1.13–1.23)

<0.001

Anxiety

1161

1.16 (1.11–1.21)

<0.001

1.14 (1.09–1.20)

<0.001

  1. Model 1 was adjusted by age, sex, Townsend deprivation index, ethnicity, and wear season. Model 2 was additionally adjusted by educational attainment, smoking status, alcohol consumption status, physical activity, BMI, and ApoE-ε4 allele.
  2. *p-value not significant after Bonferroni correction (α = 0.05/6).
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