Table 1 Basic characteristics, APOE, CRP measurement and incidence of AD in main discovery—UKBB.
Characteristic | All subjects | CRP ≥3 mg/L | P valuea (3 mg/L) | CRP ≥8 mg/L | P valuea (8 mg/L) | CRP ≥9 mg/L | CRP ≥10 mg/L | CRP ≥11 mg/L | CRP ≥12 mg/L |
|---|---|---|---|---|---|---|---|---|---|
N subjects, No. (%) | 279,176 | 67,273 (24.10) | NA | 17,173 (6.15) | NA | 14,519 (5.20) | 12,335 (4.42) | 10665 (3.82) | 9177 (3.29) |
Incidence of AD, No. (%) | 803 (0.29) | 196 (0.29) | 0.87b | 61 (0.36) | 0.10b | 50 (0.34) | 47 (0.38) | 40 (0.38) | 37 (0.40) |
Age when measuring CRP, mean (SD) | 60.07 (5.47) | 60.49 (5.43) | <0.001c | 60.54 (5.47) | <0.001c | 60.55 (5.46) | 60.58 (5.44) | 60.60 (5.45) | 60.64 (5.44) |
Age, range | 50–73 | 50–72 | NA | 50–70 | NA | 50–70 | 50–70 | 50–70 | 50–70 |
AD onset age, mean (SD) | 70.51 (4.49) | 70.49 (4.06) | 0.96c | 71.20 (3.72) | 0.14c | 70.70 (3.57) | 70.77 (3.64) | 70.42 (3.66) | 70.84 (3.29) |
Follow-up years, mean (SD) | 8.26 (0.92) | 8.29 (0.92) | <0.001c | 8.30 (0.93) | <0.001c | 8.30 (0.93) | 8.30 (0.93) | 8.29 (0.93) | 8.29 (0.93) |
Female, No. (%) | 150,542 (53.92) | 39,363 (58.51) | <0.001b | 10,171 (59.23) | <0.001b | 8530 (58.75) | 7178 (58.19) | 6128 (57.46) | 5226 (56.95) |
Years of education, mean (SD) | 18.13 (3.12) | 17.56 (3.02) | <0.001c | 17.44 (2.99) | <0.001c | 17.47 (3.02) | 17.47 (3.02) | 17.48 (3.03) | 17.49 (3.02) |
APOE ε2d, No. (%) | 37,330 (13.37) | 9,889 (14.70) | <0.001b | 2,656 (15.47) | <0.001b | 2263 (15.59) | 1928 (15.63) | 1673 (15.69) | 1452 (15.82) |
APOE ε4d, No. (%) | 67,590 (24.21) | 12,487 (18.56) | <0.001b | 2,970 (17.29) | <0.001b | 2512 (17.30) | 2118 (17.17) | 1832 (17.18) | 1583 (17.25) |
CRP, median (IQR), mg/L | 1.43 (0.72–2.90) | 5.07 (3.77–8.11) | NA | 12.47 (9.73–17.92) | NA | 13.68 (10.84–19.45) | 14.87 (11.95–21.08) | 16.10 (12.96–22.47) | 17.37 (14.09–24.11) |
