Table 2 Interactions between 10 SNPs (MAF > 5%) and continuous CRP levels on AD risk using the Cox proportional hazards regression model in UKBB.

Gene Locus	Chr:Pos (GRCh37)	Major Allele	Minor Allele	dbSNP ID	Function	MAF	Discovery UK-biobank
							Main Effect of SNP^a		Interaction Effect (SNP:CRP)^b
							HR (95%CI)	P value^c	HR (95%CI)	P value^c
CR1	1:207692049	G	A	rs6656401	Intron	0.18	1.12 (0.99–1.27)	0.06	1.01 (0.99–1.04)	0.43
*HLA-DRB1*	6:32578530	A	C	rs9271192	Intergenic	0.27	1.19 (1.07–1.32)	0.002	1.02 (0.99–1.04)	0.18
CD2AP	6:47487762	A	G	rs10948363	Intron	0.27	1.02 (0.91–1.14)	0.73	1.00 (0.98–1.03)	0.78
EPHA1	7:143109139	T	C	rs11767557	Intron	0.21	1.02 (0.91–1.15)	0.72	0.99 (0.96–1.02)	0.58
*CLU*	8:27467686	T	C	rs9331896	Intron	0.41	0.90 (0.81–0.99)	0.03	1.01 (0.98–1.03)	0.67
*SPI1*	11:47376448	A	G	rs1057233	3’ UTR	0.32	1.00 (0.90–1.12)	0.93	0.97 (0.95–0.99)	0.03
MS4A6A	11:59923508	A	G	rs983392	Intergenic	0.41	0.93 (0.84–1.03)	0.14	0.99 (0.97–1.02)	0.64
*ADAM10*	15:59045774	A	G	rs593742	Intron	0.31	0.89 (0.8–0.99)	0.04	1.00 (0.98–1.03)	0.94
ABCA7	19:1063443	G	A	rs4147929	Intron	0.18	1.06 (0.93–1.2)	0.38	1.00 (0.98–1.03)	0.83
*CD33*	19:51727962	C	A	rs3865444	5’UTR	0.32	0.83 (0.75–0.93)	<0.001	0.98 (0.95–1.01)	0.16

Using the UK Biobank (UKBB) dataset and Cox proportional hazards regression, 10 SNPs related to AD and inflammation were chosen, and their relationships and interactive effects with continuous CRP levels for AD risk were examined. Raw P values are shown.
AD Alzheimer’s disease, CRP C-reactive protein, HR hazard ratio, Chr chromosome, Pos position, MAF minor allele frequency.
^aLogistic regression for the relationship between SNP dosage alone and AD without including CRP.
^bCox proportional hazards regression models for the interaction: SNP dosage ∗ CRP level after adjusting for age, sex, years of education, APOE ε4 status and PCs. Raw P values are shown.
^cRaw P values.
Bold value indicates P < 0.05.

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