Table 3 Interaction between SNPs and high CRP on cerebral spinal fluid ABeta42, t-Tau, p-Tau in the ADNI study.

CRP level^a	Interaction Effect for CSF Biomarkers	rs1057233 (SPI1)^a		rs3865444 (CD33)^a
CRP level^a	Interaction Effect for CSF Biomarkers	Estimate (SE)	P value^a	Estimate (SE)	P value^a
3 mg/L cutoff	Abeta	−0.153 (0.181)	0.40	−0.316 (0.172)	0.07
	t-Tau	−0.146 (0.136)	0.28	−0.069 (0.130)	0.55
	p-Tau	−0.167 (0.154)	0.27	−0.046 (0.147)	0.70
8 mg/L cutoff	Abeta	0.211 (0.281)	0.46	−0.463 (0.265)	0.08
	t-Tau	−0.474 (0.213)	0.03	−0.351 (0.201)	0.07
	p-Tau	−0.520 (0.241)	0.04	−0.369 (0.227)	0.09
9 mg/L cutoff	Abeta	0.122 (0.290)	0.68	−0.465 (0.279)	0.10
	t-Tau	−0.481 (0.220)	0.03	−0.420 (0.213)	0.04
	p-Tau	−0.512 (0.249)	0.04	−0.434 (0.242)	0.06
10 mg/L cutoff	Abeta	‘0.038 (0.319)	0.90	−0.324 (0.301)	0.28
	t-Tau	−0.717 (0.238)	0.003	−0.451 (0.227)	0.04
	p-Tau	−0.766 (0.270)	0.005	−0.492 (0.257)	0.05

Different CRP cutoffs ≥3, 8, 9 and 10 mg/L were used. General linear regression (GLM) was used to study the relationships between these blood CRP cutoffs and two SNPs for AD biomarkers, including Abeta42, total Tau (t-Tau) and phosphorylated Tau (p-Tau), in cerebrospinal fluid (CSF). The models were adjusted for age, sex, years of education and APOE ɛ4. Prevalent AD was removed. Biomarkers at each last exam were used. Raw P values are shown.
^aDummy variable for SNPs and CRP in Model: rs1057233: GG + GA = 1, AA = 0; rs3865444: CA + AA = 1, CC = 0; CRP cutoff code: < cutoff=0; ≥ cutoff=1.
^bRaw P values.
Bold value indicates P < 0.05.

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