Table 1 Socio-demographic and clinical variables (n = 181).

From: Increased blood neutrophil extracellular traps (NETs) associated with early life stress: translational findings in recent-onset schizophrenia and rodent model

Variables

Controls

Patients

Siblings

p

(n = 78)

(n = 78)

(n = 25)

Male, n (%)d

54 (69.2)

54 (69.2)

8 (32.0)

0.002a,b

Age, mean (SD)e

30.3 (11.9)

30.1 (12.3)

29.8 (8.7)

0.881

Body mass index (kg/m2), mean (SD)e

26.5 (5.8)

24.0 (4.5)

25.8 (5.2)

0.035c

Tobacco smoking (yes), n (%)f

8 (10.3)

30 (38.5)

5 (20.0)

<0.001c

Lifetime psychoactive substance use (yes), n (%)f

16 (20.5)

49 (62.8)

5 (20.0)

<0.001a,c

Childhood trauma questionnaire (total score)e

38.2 (13.2)

40.7 (14.2)

41.2 (13.9)

<0.001b,c

Psychosis age of onset, mean (SD)

-

28.4 (12.2)

-

-

DUP (weeks), median (min-max)

-

20.5 (0–1292)

-

-

Pharmacological treatment (weeks), median (min-max)

-

13.0 (0–155)

-

-

Duration of psychosis (weeks), median (min-max)

-

53 (4–1394)

-

-

BPRS, mean (SD)e

0.45 (1.43)

8.41 (6.44)

0.72 (1.46)

<0.001a,c

Pharmacological treatment

Antipsychotics (AP)

-

50 (64.1)

-

-

Antidepressants (AD)

 

1 (1.3)

  

AP + AD

-

10 (12.8)

-

-

AP + Mood Stabilisers (MS)

-

6 (7.7)

-

-

AP + AD + MS

-

3 (3.8)

-

-

None

-

8 (10.3)

-

-

  1. SD Standard Deviation, DUP Duration of Untreated Psychosis, BPRS Brief Psychiatric Rating Scale.
  2. Pairwise comparison: aPatients v. Siblings; bSiblings v. Controls; cPatients v. Controls.
  3. dPearson’s Chi-square test, eKruskal–Wallis, fFisher’s Exact Test
  4. Significant results are depicted in bold.