Table 1 Sleep symptomatology in children with an ND-GC and control siblings.

From: Sleep disturbance as a transdiagnostic marker of psychiatric risk in children with neurodevelopmental risk genetic conditions

Trait

ND-GC

Control

p value

(N = 629)

(N = 183)

Any sleep problem

66% (415)

39% (72)

<0.001

Insomnia

41% (255)

17% (31)

<0.001

Initial insomnia

25% (156)

15% (28)

0.018

Middle insomnia

14% (88)

2% (4)

<0.001

Early insomnia

24% (154)

4% (8)

<0.001

Hypersomnia

8% (53)

2% (4)

0.004*

Restless sleep

36% (228)

14% (26)

<0.001

Unrested from sleep

16% (98)

4% (8)

<0.001

Tiredness

9% (54)

2% (4)

<0.001

Fatigability

7% (44)

2% (4)

0.001

Nightmares

16% (103)

12% (22)

0.302*

Night Terrors

9% (55)

3% (5)

0.001

Somnambulism

8% (50)

9% (16)

0.403

  1. p values derived from mixed effect models controlled for sex, age, fixed effects, and relatedness as a random effect. p values in bold remained significant following BH-FDR correction for multiple testing.
  2. * mixed effect models for binary outcomes failed to converge, so logistic regression models with sex and age as covariates were conducted.
Back to article page