Table 2 Multiple linear regression analyses in the whole sample of patients with schizophrenia-spectrum and bipolar disorders, with cognitive performance as the dependent variable and adherence behavior, sex, age, duration of illness, number of prescribed medications, and diagnosis as the predictors.

Patients with schizophrenia-spectrum and bipolar disorders
		Unstandardized		Standardized	t value	p value	R²	R²_a	df1	df2
		USC B	SE	SC B	t value	p value	R²	R²_a	df1	df2
Learning and memory						<0.001*	0.031	0.024	5	808
	Adherence scale	−0.03	0.03	−0.04	−1.10	0.270
	Sex	−0.02	0.07	−0.01	−0.30	0.765
	Age	−0.01	0.00	−0.13	−3.09	0.002**
	Illness duration	0.00	0.00	0.01	0.13	0.899
	No. of medications	−0.04	0.03	−0.05	−1.52	0.130
	Diagnosis	0.27	0.07	0.14	3.78	<0.001*
Executive function						<0.001*	0.110	0.104	5	808
	Adherence scale	0.00	0.026	−0.001	−0.028	0.978
	Sex	−0.01	0.067	−0.004	−0.121	0.904
	Age	−0.02	0.003	−0.302	−7.35	<0.001**
	Illness duration	0.00	0.004	−0.001	−0.037	0.971
	No. of medications	−0.08	0.026	−0.103	−3.042	0.002**
	Diagnosis	0.34	0.068	0.171	4.946	<0.001**
Psychomotor speed						<0.001*	0.202	0.196	5	808
	Adherence scale	−0.038	0.023^a		−1.59	0.111
	Sex	0.173	0.061^a		2.80	0.005**
	Age	−0.028	0.003^a		−9.88	<0.001**
	Illness duration	−0.004	0.004^a		−1.20	0.23
	No. of medications	−0.092	0.024^a		−3.88	<0.001**
	Diagnosis	0.493	0.062^a		7.75	<0.001**
GAF						<0.001*	0.159	0.153	5	808
	Adherence scale	−1.424	0.335	−0.141	−4.253	<0.001**
	Sex	0.885	0.873	0.033	1.014	0.311
	Age	0.046	0.043	0.043	1.072	0.284
	Illness duration	−0.028	0.052	−0.021	−0.546	0.585
	No. of medications	−2.226	0.343	−0.213	−6.493	<0.001**
	Diagnosis	7.693	0.893	0.29	8.618	<0.001**

df degrees of freedom, HC heteroscedasticity consistent, SC B standardized coefficient, SE standard error, USC B unstandardized coefficient β.
*p < 0.05 significant; **p < 0.008 significant (Bonferroni corrected for multiple testing).
^aRobust standard errors after HC4 correction.

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