Fig. 5: Partial regression plot illustrating the relationship between residuals of the natural log transformed plasma concentrations of interleukin (IL)-6 and residualized change in Hamilton Depression Rating Scale (HDRS) score.

The Pearson correlation between the two sets of residuals is equal to the partial correlation between HDRS scores at week 2 post-WBH/sham treatment and the natural log transformed concentration of plasma IL-6 assessed immediately post-WBH/sham treatment (controlling for baseline HDRS scores and baseline natural log transformed concentration of plasma IL-6, respectively). HDRS Hamilton Depression Rating Scale, IL interleukin, WBH whole-body hyperthermia.