Fig. 1: Conceptual framework for exploring transcriptional dynamics of MDD in the brain. | Translational Psychiatry

Fig. 1: Conceptual framework for exploring transcriptional dynamics of MDD in the brain.

From: Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings

Fig. 1

Transcription dysregulation associated with depression is dynamic from predisposition to onset to illness; it is influenced by environmental exposures, contexts, and genetics, and can be studied from a variety of experimental approaches. GWAS genome-wide association study, TI transcriptomic imputation, iPSC induced pluripotent stem cells. Created with BioRender.com.

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