Fig. 3: Mapping gene-level associations for depression from predisposition to illness. | Translational Psychiatry

Fig. 3: Mapping gene-level associations for depression from predisposition to illness.

From: Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings

Fig. 3

A Conceptual representation of analysis and potential interpretations for dynamic MDD gene expression associations. Predisposition: dorsolateral prefrontal cortex (DLPFC) genetically regulated expression associations were predicted with S-PrediXcan using MDD GWAS [3] and CommonMind Consortium DLPFC eQTL predictor model [71]. Illness: MDD vs healthy control differentially expressed genes [3, 4] were meta-analyzed using a fixed-effects inverse variance method. B Z-scores for GREx (predisposition) and postmortem (illness) associations of MDD vs controls are plotted. C Gene set enrichment (g:Profiler [155]) of top concordant and discordant genes (p < 0.05) from analysis in (B). GREx genetically regulated expression, PM postmortem. Created with BioRender.com.

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