Fig. 3: Visualisation of the significant association between the schizophrenia PRS and the regions of interest in the European ancestry cohort (n = 207).

A–D Scatter plots of infant brain volume against Schizophrenia PRS at P_T = 0.001. Brain volumes have been adjusted for GA, PMA, sex and ICV. PRS have been adjusted for the first 3 ancestral principal components. Axes are standardised to zero mean and unit variance. The shaded area denotes the confidence interval (E): Bar plot of brain volume variance R² explained by PRS, calculated as the difference between the R² of the full model with PRS as a covariate and that of the null model without the PRS as a covariate. *nominal significant result; **result surviving multiple testing correction. F, G Visualisation of the significant associations between the PRS at P_T = 0.001 and brain volumes of white (F) and grey matter (G) regions of interests. Colour bar denotes the range of –log₁₀(p-value). (FL.R- right frontal lobe, STG.R- right superior temporal gyrus).