Fig. 4: Top five enriched pathways and their corresponding gene lists as calculated by FUMA [46]. | Translational Psychiatry

Fig. 4: Top five enriched pathways and their corresponding gene lists as calculated by FUMA [46].

From: Effect of schizophrenia common variants on infant brain volumes: cross-sectional study in 207 term neonates in developing Human Connectome Project

Fig. 4

Top: bar plot of –log(p-value) of SNPs mapped to genes in gene list ordered by their association with the right frontal lobe white matter in the European cohort. Numbers on the bar denote the number of SNPs if more than 1 SNP associated with right frontal lobe white matter is mapped to that gene. Colours in the bar plot denote the –log(p-value) of the SNPs (the most associated SNP if there are more than 1 for that corresponding gene) with schizophrenia as calculated by schizophrenia GWAS [21]. Bottom: Enriched gene sets and their overlapping gene list (shown are the top 30 genes ordered by their p-value association with the right frontal lobe white matter). Blue square- the gene in the gene list is present in that pathway. Left: bar plot of the gene-set enrichment adjusted p-value. Colours denote the proportion of genes in the gene set found in the gene list. GO_BP – Gene Ontology Biological Processes.

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