Fig. 1: Six target genes showed a relationship with the diagnosis that survived false discovery rate correction (FDR < 0.10) in our BA10 qPCR experiment. | Translational Psychiatry

Fig. 1: Six target genes showed a relationship with the diagnosis that survived false discovery rate correction (FDR < 0.10) in our BA10 qPCR experiment.

From: Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia

Fig. 1

Boxplots illustrate the distribution of −ΔΔCq values (log2 fold change (Log2FC), with the average for the CTRL group set as 0) for each subject within each diagnosis group (boxes=first quartile, median, and third quartile, whiskers = range and/or 1.5× the interquartile range if there are outlying data points). For ease of visualization, each datapoint represents an average of the individual replicates for each subject, without the additional correction for influential sources of biological variation (age, pH, sex) or technical variation (PMI, RIN, RNA Concentration, Card) provided by our multilevel statistical model (statistics reported below). A 5-Hydroxytryptamine Receptor 2B (HTR2B) showed an effect of diagnosis (P = 0.000312, FDR = 0.0173), with a decrease in both bipolar disorder (BP, Log2FC = -0.681, P = 0.0270) and schizophrenia (SCHIZ, Log2FC = -0.980, P = 0.000903). B Dopamine Receptor D4 (DRD4) showed an effect of diagnosis (P = 0.00196, FDR = 0.0495), with a decrease in both BP (Log2FC = -0.466, P = 0.00510) and SCHIZ (Log2FC = -0.347, P = 0.0244). C Somatostatin (SST) showed an effect of diagnosis (P = 0.00223, FDR = 0.0495), with a trend towards a decrease in BP (Log2FC = −0.308, P = 0.0935) and a decrease in SCHIZ (Log2FC = -0.467, P = 0.00689), D 4-aminobutyrate aminotransferase (ABAT) showed an effect of diagnosis (P = 0.00166, FDR = 0.0495), with elevation in BP (Log2FC = 0.157, P = 0.00550) and a trend towards elevation in SCHIZ (Log2FC = 0.083, P = 0.0993). E Gephyrin (GPHN) showed an effect of diagnosis (P = 0.000283, FDR = 0.0173), with elevation in BP (Log2FC = 0.156, P = 0.00256) and SCHIZ (Log2FC = 0.101, P = 0.0295). F Mitogen-activated protein kinase 1 (MAPK1) showed an effect of diagnosis (P = 0.00372, FDR = 0.0688), with elevation in BP (Log2FC = 0.135, P = 0.00113) and a trend towards elevation in SCHIZ (Log2FC = 0.0869, P = 0.0730). Complete statistical reporting for the full concatenated qPCR results can be found in Supplementary Table S5.

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