Fig. 3: Bioinformatic analysis of black gene module by IPA.

A A canonical pathway of the neuroinflammation signaling pathway is downregulated in patients with schizophrenia. Genes highlighted in pink are included in the black module; red represents upregulated expression while green represents downregulated expression. Genes noted in orange were predicted to be upregulated, while those noted in blue were predicted to be downregulated. The orange line represents the expression state of consistent activation between the upstream regulator and the gene. The blue line represents the expression state of consistent inhibition between the upstream regulator and the gene. The yellow line represents an inconsistent relationship between the upstream regulator and the gene. The gray line represents no prediction information related to the expression status. B LPS is an upstream regulator that modulates gene expression in the black module. Genes noted in red were upregulated, while those noted in green were downregulated. Line colors have the same meaning as in (A).