Table 5 Drug Liking bipolar VAS Emax—Ketamine Study.

From: The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users

 

Ketamine Study

Statistic

Esmethadone 25 mg (N = 51)

Esmethadone 75 mg (N = 51)

Esmethadone 150 mg (N = 51)

Ketamine 0.5 mg/kg (N = 51)

DXM 300 mg (N = 51)

Placebo (N = 51)

Mean (SD)

51.4 (3.28)

54.9 (9.58)

59.2 (14.38)

90.0 (14.52)

68.4 (18.39)

50.9 (2.23)

Median

50.0

50.0

51.0

100.0

60.0

50.0

Range

50–66

50–100

50–100

50–100

50–100

50–63

  1. Drug Liking VAS is a bipolar scale where a score of 0 represents “strong disliking,” a score of 100 represents “strong liking,” and a score of 50 represents “neither like nor dislike” (neutral point). The question text is, “At this moment, my liking for this drug is?”.
  2. Emax maximum effect, range minimum–maximum, SD standard deviation, VAS visual analog scale. Esmethadone and DXM were oral administration; ketamine IV administration.
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