Fig. 3: Stress-induced depression-like behaviors are correlated with spontaneous behavioral profiles.

A Schematic diagram of the behavioral tests. B Summary of the correlation analysis between depression-like behaviors and the fraction of each spontaneous behavior. The numbers above the dots indicate the correlation coefficient. C, D Representative correlation analysis between depression-like behaviors and the fraction of each spontaneous behavior. E Summary of the correlation analysis between behavioral transitions and two depression-like behaviors. The arrows between two behavioral states indicate the direction of transition. The numbers above the arrow indicate the correlation coefficient. See also Fig. S6. F Pipeline for ElasticNet linear regression model construction and prediction. G Model prediction of depression-like behaviors (left) and residual histograms (right). Coefficient of determination (R²) were labeled. H Measurement (up) and Prediction (down) values of depression-like behaviors were shown in the ‘Immobility time × sucrose preference × social ratio’ space. I K-means clustering (k = 4) of measurement (up) and prediction (down) values of immobility time and social ratio. Samples belonging to the same cluster in measurement and prediction clusters are labeled with yellow circles in the prediction data. Pearson correlation analysis.