Fig. 1: Proposed functions of MACF1 in the therapeutic pathway of lithium in BPAD. | Translational Psychiatry

Fig. 1: Proposed functions of MACF1 in the therapeutic pathway of lithium in BPAD.

From: Role of microtubule actin crosslinking factor 1 (MACF1) in bipolar disorder pathophysiology and potential in lithium therapeutic mechanism

Fig. 1

Lithium (and DISC1 endogenously) inhibits GSK3B, raising levels of active MACF1. Active MACF1 then functions (through domains added in italics) in neurons to re-normalize pathologically altered neuronal structure and function in treating BPAD symptomology. MACF1 microtubule actin crosslinking factor 1, pMACF1 phosphorylated microtubule actin crosslinking factor 1, BPAD bipolar affective disorder, DISC1 disrupted in schizophrenia 1, GSK3B glycogen synthase kinase 3β, MT microtubule, CH calponin homology, GAR Gas2-related, SH3 Src-homology-3, SRD spectrin repeat domain, PRd plakin repeat domain, LTP long-term potentiation. Created with Biorender.com.

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