Table 2 Functional analysis of significant protein modules.

BP

Proteolysis

32

5.69E−15

1.31E−11

Plasma lipoprotein particle remodeling

8

1.14E−10

1.82E−07

Protein activation cascade

14

2.47E−14

2.84E−11

Protein–lipid complex remodeling

8

1.14E−10

1.82E−07

Complement activation

13

1.63E−13

1.25E−10

Macromolecular complex remodeling

8

1.86E−10

1.99E−07

Humoral immune response

15

3.51E−11

2.01E−08

Plasma lipoprotein particle organization

8

2.80E−09

2.25E−06

Response to external stimulus

32

2.72E−10

1.23E−07

Lipid transport

16

3.94E−09

2.36E−06

CC

Extracellular space

54

4.35E−37

1.30E−34

Extracellular region part

68

6.18E−22

2.42E−19

Extracellular region part

58

1.37E−27

2.03E−25

High-density lipoprotein particle

13

3.87E−20

7.58E-18

Blood microparticle

20

1.82E−24

1.81E−22

Extracellular space

49

1.18E−19

1.54E−17

Extracellular region

58

4.06E−23

3.02E−21

Plasma lipoprotein particle

13

1.67E−18

1.31E−16

Extracellular vesicle

40

3.72E−18

1.90E−16

Lipoprotein particle

13

1.67E−18

1.31E−16

MF

Serine-type endopeptidase inhibitor activity

10

2.25E−10

6.69E−08

Cell adhesion molecule binding

15

1.14E−06

4.73E−04

Endopeptidase inhibitor activity

11

2.80E−09

3.78E−07

Receptor binding

26

5.02E−06

1.04E−03

Peptidase inhibitor activity

11

3.99E−09

3.78E−07

Lipid binding

17

1.06E−05

1.46E−03

Endopeptidase regulator activity

11

5.09E−09

3.78E−07

Enzyme inhibitor activity

12

1.54E−05

1.60E−03

Peptidase regulator activity

11

3.02E−08

1.62E−06

Serine-type endopeptidase inhibitor activity

7

2.06E−05

1.71E−03

KEGG

Complement and coagulation cascades

20

1.61E−26

2.18E−24

Cholesterol metabolism

9

7.00E−09

1.16E−06