Table 3 Associations of brain structure with physical symptoms.

From: Physical symptoms and brain morphology: a population neuroimaging study in 12,286 pre-adolescents

Generation R study (n = 2649)

Cortical grey matter volume (mm3)

Subcortical grey matter volume (mm3)

Total white matter volume (mm3)

b

SE

punc

pFDR

b

SE

punc

pFDR

b

SE

punc

pFDR

Physical symptoms

−6.3 × 10−7

6.5 × 10−7

0.337

0.755

−2.2 × 10−6

6.0 × 10−6

0.716

0.755

−4.5 × 10−7

7.5 × 10−7

0.551

0.755

Adolescent Brain Cognitive Development (ABCD) study (n = 9637)

Cortical grey matter volume (mm3)

Subcortical grey matter volume (mm3)

Total white matter volume (mm3)

b

SE

punc

pFDR

b

SE

punc

pFDR

b

SE

punc

pFDR

Physical symptoms

−8.1 × 10−8

2.6 × 10−7

0.755

0.755

−2.1 × 10−6

3.2 × 10−6

0.510

0.755

-4.1 x10-7

3.2 × 10−7

0.199

0.755

  1. b Unstandardised Coefficient Regression, SE Standard Error, unc uncorrected, FDR False Discovery Rate.
  2. The model was adjusted for age, sex, national origin (Generation R) or race/ethnicity (ABCD), estimated intracranial volume, maternal education (Generation R) or parental education (ABCD), household income, body mass index and non-verbal intelligence quotient. ABCD analyses were additionally adjusted for the 21 study sites. Physical symptoms were assessed using the school-age version (for ages 6–18) of the Child Behavior Checklist (CBCL).