Table 1 Demographic and clinical data from healthy controls and CD patients.
Healthy controls (N = 57) | CD patients (N = 50) | Healthy controls vs. CD patients (p-value) | ||||
|---|---|---|---|---|---|---|
Mean (SD) | Min-Max | Mean (SD) | Min-Max | |||
Age(year) | 35.421(11.098) | 20–63 | 37.960(10.728) | 15–62 | 0.233 | |
Education(year) | 12.350(3.286) | 5–17 | 11.040(4.015) | 3–18 | 0.070 | |
Gender(m/f) | 0/57 | – | 0/50 | – | – | |
Disease duration(month) | – | – | 43.370(53.698) | 1–300 | – | |
Plasma cortisol level (nmol/L) | 00:00 | – | – | 603.612(226.104) | 290.420–11179.600 | – |
08:00 | – | – | 710.909(280.709) | 221.440–1691.400 | – | |
16:00 | – | – | 638.121(236.342) | 208.990–1534.740 | – | |
ACTH (nmol/L) | 00:00 | – | – | 14.159(7.655) | 3.640–40.200 | – |
08:00 | – | – | 18.644(15.443) | 2.310–72.400 | – | |
16:00 | – | – | 17.498(10.850) | 3.220–51.100 | – | |
UFC (nmol/24 h) | – | – | 2156.4372(1409.0234) | 423.500–6777.400 | – | |
Cushing QOL | – | – | 36.617(8.894) | 20–55 | – | |
SDS | 32.000(3.533) | 25–42 | 49.425(12.379) | 27–76 | <0.001 | |
SAS | 24.631(3.642) | 20–34 | 37.893(7.777) | 24–59 | <0.001 | |
CNPI | – | – | 11.000(10.836) | 0–46 | – | |
MoCA-BJ | Visuospatial/Executive | 4.777(0.540) | 3–5 | 3.173(1.141) | 0–5 | <0.001 |
Naming | 2.777(0.421) | 2–3 | 2.326(0.844) | 0–3 | 0.002 | |
Memory | 4.305(0.920) | 2–5 | 2.565(1.544) | 0–5 | <0.001 | |
Attention | 5.833(0.447) | 4–6 | 5.087(1.170) | 0–6 | <0.001 | |
Language | 2.472(0.608) | 1–3 | 2.000(0.788) | 0–3 | 0.004 | |
Abstraction | 1.722(0.566) | 0–2 | 1.369(0.770) | 0–2 | 0.019 | |
Orientation | 6.000(0) | 6–6 | 5.804(0.542) | 4–6 | 0.018 | |
MoCA-BJ total score | 27.889(2.135) | 21–30 | 22.369(4.428) | 8–29 | <0.001 | |
