Fig. 1: Autistic-like core behaviors in Shank1 P1812L-KI HET mice but not in HOM mice. | Translational Psychiatry

Fig. 1: Autistic-like core behaviors in Shank1 P1812L-KI HET mice but not in HOM mice.

From: Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice

Fig. 1

Social novelty deficits in P1812L-KI HET mice in the three-chamber social test (n = 14–16 for each genotype) (A, B). A Social interaction. S #1, a stranger mouse. O, a novel object. B Social novelty preference. S #1, a familiar, previously investigated mouse. S #2, a novel unfamiliar mouse. C Increased RRBs in P1812L-KI HET mice in the marble-burying test (n = 17–20 for each genotype). D Normal locomotion in P1812L-KI mice in the open field test (n = 12–15 for each genotype). No anxiety-like behavior in P1812L-KI mice, as measured by the center activity in the open field test (E), the light-dark box test (F) (n = 12–14 for each genotype) and the elevated plus maze test (G) (n = 8–10 for each genotype). H Normal short-term (Day 5) spatial memory in P1812L-KI mice in the Barnes maze (n = 13–14 for each genotype). I Deficits in long-term (Day 12) spatial memory in P1812L-KI HOM mice, as indicated by both parameters. Paired Student’s t test for (A, B). One-way ANOVA for (C–I). All data are presented as the mean ± SE. ns, no significance, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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