Fig. 3: Downregulation of mGluR and downstream signaling pathways in glutamatergic synapses in Shank1 P1812L-KI HET mice but not in HOM mice. | Translational Psychiatry

Fig. 3: Downregulation of mGluR and downstream signaling pathways in glutamatergic synapses in Shank1 P1812L-KI HET mice but not in HOM mice.

From: Downregulation of mGluR1-mediated signaling underlying autistic-like core symptoms in Shank1 P1812L-knock-in mice

Fig. 3

A mGluR1 and Homer2 were decreased in P1812L-KI HET mice. GluA2 was increased in P1812L-KI HOM mice. B PKA and p-ERK1/2 were decreased in P1812L-KI HET mice. IP3R1 and p-CaMKII were increased in P1812L-KI HOM mice. For (A) and (B), the left side shows representative bands for the indicated proteins; each lane was loaded with protein samples from an individual mouse. The right side shows the corresponding statistical results, normalized to WT levels. β3-Tubulin, serving as a loading control, is displayed in (A). The results were obtained from at least three mice per genotype and performed at least in duplicate. All data are presented as the mean ± SE. *P < 0.05, **P < 0.01, ***P < 0.001 for groups compared with WT, by one-way ANOVA.

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