Fig. 3: Analysis of Z-activation score in different brain regions following PNS exposure in male and female adolescent offspring. | Translational Psychiatry

Fig. 3: Analysis of Z-activation score in different brain regions following PNS exposure in male and female adolescent offspring.

From: Vulnerability and resilience to prenatal stress exposure: behavioral and molecular characterization in adolescent rats

Fig. 3

The Z-Activation score was calculated based on the analysis of IEGs expression (Arc, Npas4, Zif-268 and C-fos) in prefrontal cortex (A, B), amygdala (C, D), dorsal hippocampus (E, F), and ventral hippocampus (G, H) of male and female offspring. The analyses were performed as whole PNS group (A, C, E, and G) or after the separation in vulnerable (PNS-vul) and resilient (PNS-res) to the gestational manipulation (B, D, F, and H). Statistical analysis for panels A, C, E, and G: two-way ANOVA, sex effect, ****p < 0.0001; PNS effect, *p < 0.05; Tukey’s post hoc, *p < 0.05, ***p < 0.001, statistically different from CT male (n = 14 to 30 per group). Statistical analysis for panels B, D, F, and H: one-way ANOVA, Tukey’s post hoc, *p < 0.05, **p < 0.01, statistically different from CT male, #p < 0.05, statistically different from the CT and PNS-vul male groups (n = 5 to 19 per group).

Back to article page