Fig. 3: Doublecortin (DCX) and Stathmin 1 (STMN1) expression in the dentate gyrus. | Translational Psychiatry

Fig. 3: Doublecortin (DCX) and Stathmin 1 (STMN1) expression in the dentate gyrus.

From: Electroconvulsive therapy is associated with increased immunoreactivity of neuroplasticity markers in the hippocampus of depressed patients

Fig. 3

The first part shows representative images of DCX expression in the granule cell layer (GCL), subgranular zone (SGZ), and cornu ammnois 4 (CA4) in a healthy control donor (HC; 1A), a control donor with a depressive disorder (DC; 1B), and a donor who received electroconvulsive therapy during life (ECT; 1C). Note the substantial signal in the GCL, SGZ, and CA4 where many positive cells were found. Quantification of the overall optical density and the distribution of the groups is shown in percentages of positive DCX cells in the GCL (1D), SGZ (1E), and CA4 (1F). In the SGZ, the mean percentage of positive DCX cells was significantly higher in the ECT group than in the HC (p = 0.003) and DC (p = 0.040) groups. In the CA4, the mean percentage of positive DCX cells was also significantly higher in the ECT group than in the HC group (p = 0.027). The second part shows representative images of STMN1 expression in the GCL and SGZ in a HC (2A), a DC (2B), and a ECT donor (2C). Quantification is shown in percentage of positive STMN1 cells in the GCL (2D) and SGZ (2E). In the SGZ, the percentage of positive STMN1 cells was significantly higher in the ECT group than in the HC (p = 0.004) and DC (p = 0.004) groups. Scale bar = 50 µm.

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