Fig. 4: NAD+ production and KP minor metabolites. | Translational Psychiatry

Fig. 4: NAD+ production and KP minor metabolites.

From: Impact of IDO activation and alterations in the kynurenine pathway on hyperserotonemia, NAD+ production, and AhR activation in autism spectrum disorder

Fig. 4

A Plasma levels of NAD+ in controls (n = 106) and individuals with ASD (n = 90). B Relationship between plasma and platelet NAD+ in controls (n = 10) and individuals with ASD (n = 9). C Oxytocin (OT) plasma levels in controls (n = 106) and individuals with ASD (n = 90). D Relationship between plasma NAD+ and OT in controls (green) and individuals with ASD (magenta). E Relationship between plasma NAD+ and IL1β levels in controls (n = 8), individuals with ASD and KYN/TRP ≤ 5% (n = 9), and individuals with ASD and KYN/TRP ≤ 5% (n = 15). Intergroup comparisons were performed using the sum-rank Wilcoxon test; the correlations were calculated using linear regression (R2) or Spearman’s correlation coefficient (ρ).

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