Fig. 2: Graphs of parameter output and correlations of changes in parameters with MADRS. | Translational Psychiatry

Fig. 2: Graphs of parameter output and correlations of changes in parameters with MADRS.

From: Neurophysiological evidence that frontoparietal connectivity and GABA-A receptor changes underpin the antidepressant response to ketamine

Fig. 2

(Panel 2.1) A–D shows the means and standard error of the mean of forward and backward extrinsic connectivity for the pre (PRE), bolus (BOL) and infusion (INF) time points. Only (A), forward, AMPA mediated connectivity, was significant in a repeated measures ANOVA. This change (infusion minus pre) was correlated with the change in depressive symptoms at 24 h, as measured by the MADRS (box E). (Panel 2.2) A shows the means and standard error of the mean of the AMPA, NMDA and GABAA receptor time constants for each region, at each time point (pre, bolus and infusion). Before FDR correction, both the frontal GABAAR and parietal NMDA receptor demonstrated significant effects, however, only the frontal GABAAR effect (of a reduced time constant), survived correction. This change in GABAAR time constant correlated with a change in depressive symptoms at 24 h post-infusion (box B, measured as change in MADRS at 24 h vs. pre-infusion). There was no statistically significant correlation for the parietal NMDAR time constant (box C).

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