Fig. 1: Overview of probabilistic classification model workflow. | Translational Psychiatry

Fig. 1: Overview of probabilistic classification model workflow.

From: Development of an individualized risk calculator of treatment resistance in patients with first-episode psychosis (TRipCal) using automated machine learning: a 12-year follow-up study with clozapine prescription as a proxy indicator

Fig. 1

A We split our data using random subsampling. The former approach was the main analysis of the current study. We randomly split the participants into train (75%) and test data sets and repeat this procedure 100 times to obtain a stable performance. The latter approach aims to examine the generalization of our models. B AutoML was implemented in Python using the TPOT package. C Bagging procedure is added when re-training the best model from autoML. D Calibration was performed using Platt scaling. E Evaluation of the performance of test data includes area under the receiver operating characteristic curve (AUROC), decision curve analysis and feature importance.

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