Table 1 Demographics.

From: Blood epigenome-wide association studies of suicide attempt in adults with bipolar disorder

 

Discovery cohort (N = 239)

Replication cohort (N = 95)

Group

BD/non-SA (n = 79)

BD/SA (n = 84)

CON (n = 76)

pBD/SA vs. BD/non-SA

BD/non-SA (n = 47)

BD/SA (n = 48)

pBD/SA vs. BD/non-SA

Age, mean (SD)

36.7 (11.5)

35.3 (10.9)

33.8 (10.5)

0.48

39.6 (13.8)

44.3 (12.9)

0.08

Sex, n female (%)

59 (75%)

59 (70%)

49 (64%)

0.60

20 (43%)

14 (29%)

0.20

Race/Ethnicity

   

0.39

  

0.22

Non-Hispanic White, n (%)

31 (39%)

39 (46%)

17 (22%)

–

39 (83%)

35 (73%)

–

Black African-American, n (%)

24 (30%)

24 (29%)

28 (37%)

–

0 (0%)

4 (8%)

–

Hispanic or Latino, n (%)

12 (15%)

15 (18%)

19 (25%)

–

4 (9%)

6 (13%)

–

Other race, n (%)

12 (15%)

6 (7%)

11 (14%)

–

4 (9%)

3 (6%)

–

Years of education, mean (SD)

14.3 (2.7)

13. 9 (2.5)

15.8 (2.4)

0.10

15.3 (2.1)

14.8 (2.3)

0.26

Self-reported smoking history, n (%)

26 (33%)

30 (36%)

2 (3%)

0.74

5 (11%)

14 (29%)

0.04

Psychiatric medication, n (%)

70 (89%)

71 (85%)

0 (0%)

0.64

42 (89%)

44 (92%)

0.74

Lithium, n (%)

18 (23%)

15 (18%)

0 (0%)

0.41

20 (43%)

6 (13%)

0.0012

Anticonvulsant, n (%)

27 (34%)

31 (37%)

0 (0%)

0.30

19 (40%)

26 (54%)

0.22

Antidepressant, n (%)

31 (39%)

28 (33%)

0 (0%)

1.00

26 (55%)

33 (69%)

0.21

Antipsychotic, n (%)

35 (44%)

42 (50%)

0 (0%)

0.12

24 (51%)

26 (54%)

0.84

Sedative, n (%)

17 (22%)

19 (23%)

0 (0%)

0.56

14 (30%)

25 (52%)

0.037

Stimulant, n (%)

1 (1%)

4 (5%)

0 (0%)

0.20

4 (9%)

6 (13%)

0.74

Number of SA, mean (SD)

–

1.79 (1.50)

–

–

–

3.98 (5.21)

–

MADRS, mean (SD)

11.0 (9.5)

16.0 (10.3)

0.16 (0.49)

0.0016

11.9 (8.7)

16.2 (9.0)

0.0017

YMRS, mean (SD)

5.2 (6.4)

7.1 (8.2)

0.20 (0.49)

0.072

5.4 (5.5)

8.2 (8.3)

0.070

  1. Demographic and clinical characteristics of the discovery and replication cohorts.
  2. p-values for quantitative variables were calculated using either t-test or Mann–Whitney U-test, depending on the result of a Shapiro–Wilk test for normality. p-values for categorical variables were calculated using the Fisher test. Bolded values indicate p < 0.05.
  3. BD bipolar disorder, CON controls, MADRS Montgomery-Asberg Depression Rating Scale, SA suicide attempt, SD standard deviation, YMRS Young Mania Rating Scale.
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