Fig. 3: Hippocampal and precuneus volume according to PET/plasma groups.

Association between brain volume assessed by MRI and PET/plasma groups were analyzed using general linear model adjusted for age, sex, estimated intracranial volume and MRI field strength. Bilateral hippocampal (A, B) and precuneus (C, D) volume according to PET/plasma groups using IP-MS-WashU and bilateral hippocampal (E, F) and precuneus (C, D) volume according to PET/plasma groups using IA-Elc (G, H). Abbreviations: IA-Elc Elecsys immunoassay from Roche Diagnostics, IP-MS-WashU immunoprecipitation followed by mass spectrometry method developed at Washington, Lt left, MRI magnetic resonance image, PET positron emission tomography, Rt right.