Fig. 4: Cross-sectional cognitive performance and longitudinal cognitive decline according to PET/plasma groups. | Translational Psychiatry

Fig. 4: Cross-sectional cognitive performance and longitudinal cognitive decline according to PET/plasma groups.

From: Characteristics of discordance between amyloid positron emission tomography and plasma amyloid-β 42/40 positivity

Fig. 4

Association between cross-sectional cognitive performance and PET/plasma groups were analyzed using general linear model adjusted for age, sex, and education levels. MMSE, CDR SB, ADNI MEM, and ADNDI EF scores according to PET/plasma groups using IP-MS-WashU (A–D) and IA-Elc (H–K). Association between longitudinal cognitive changes and PET/plasma groups were analyzed linear mixed model adjusted for age, sex, and education levels. MMSE, CDR SB, and ADNI MEM changes according to PET/plasma groups using IP-MS-WashU (E–G) and IA-Elc (L–N). Abbreviations: ADNI EF Alzheimer’s Disease Neuroimaging Initiative composite score of executive function, ADNI MEM Alzheimer’s Disease Neuroimaging Initiative composite score of memory, CDR SB clinical dementia rating sum of boxes, IA-Elc Elecsys immunoassay from Roche Diagnostics, IP-MS-WashU immunoprecipitation followed by mass spectrometry method developed at Washington, MMSE mini mental state examination, PET positron emission tomography.

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