Fig. 2: Psychiatric disorder associated genes identified by differential expression in brain tissue, GWAS, EWAS in relation to immune systems.
From: Genetic evidence for causal effects of immune dysfunction in psychiatric disorders: where are we?
A Genes identified by differential expression in brain tissue by Gandal et al. [66] for autism spectrum disorder (ASD), bipolar disorder (BIP), and schizophrenia (SCZ) are annotated to genes involved in innate immune response (InnateDB, https://www.innatedb.com/) and ImmPort (https://www.immport.org/). Proportions of reported genes annotated to each immune gene source are shown on y axis. The number of annotated genes and reported genes are shown on the top of each bar. WordCloud plots for reported genes annotated to ImmPort (C) and InnateDB (B). Wordcloud plots for reported genes identified by brain tissue expression, GWAS and EWAS annotated to ImmPort (D) and InnateDB (E). Text font sizes indicate the number of disorders associated with the gene.
