Fig. 2: The results of voxel-based unbiased brain-wide association study in DS and NDS groups. | Translational Psychiatry

Fig. 2: The results of voxel-based unbiased brain-wide association study in DS and NDS groups.

From: Convergent and divergent genes expression profiles associated with brain-wide functional connectome dysfunction in deficit and non-deficit schizophrenia

Fig. 2

Anatomical location of consistently altered functional connectivity in DS (A) and NDS (B) obtained from voxel-based BWAS. Manhattan plot of voxel-based unbiased brain-wide association study results indicating that DS showed significantly altered functional links compared to CN. Each dot represents a functional connectivity link between two voxels. Note there are a total of 23,178 × 23,178/2 links, and we only plot a significant dot if Cluster defining threshold (z-value) > 7. The red dotted line is the whole-brain FWE correction threshold p = 7.22 × 10−48. The regions indicate the AAL3 atlas regions in which the voxels were located, with the numbers for each region specified in Table S1. The glass brains indicated the anatomical location of the voxels showing significantly altered functional connectivity with other voxels (FWE < 0.05). The color bar indicates the measure of association (MA, see text) given by the number of significantly affected links relating to each voxel. We presented clusters voxels containing more than 100 significant voxels (MA > 40). DS deficit schizophrenia, NDS non-deficit schizophrenia, CN healthy controls.

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