Fig. 5: Enrichment of overlapped genes between DS and NDS and spatio-temproal patterns of identified key genes. | Translational Psychiatry

Fig. 5: Enrichment of overlapped genes between DS and NDS and spatio-temproal patterns of identified key genes.

From: Convergent and divergent genes expression profiles associated with brain-wide functional connectome dysfunction in deficit and non-deficit schizophrenia

Fig. 5

A Indicating GO enrichment of positive and negative overlapped genes between DS and NDS (a, c), and indicating the relationships between identified genes and top five significant pathways (b, d). B Indicating KEEG enrichment and the relationships between identified genes and significant pathways. C Indicating genes expression differences and spatio-temporal expression patterns of the identified key genes. Each changing curve represents the change in gene expression throughout the lifespan. The box plot represents differences in gene expression of these two key genes in schizophrenia patients compared with healthy controls (Note: the box plot is from SZDB, http://www.szdb.org/). p < 0.001. DS deficit schizophrenia, NDS non-deficit schizophrenia, DSS differential stability score, WGCNA weighted gene co-expression network analysis, AHBA Allen Human Brain Atlas, SZDB A Database for Schizophrenia Genetic Research (http://www.szdb.org/), BP biological processes, CC cellular components, MF molecular function, OFC orbital prefrontal cortex, DFC dorsolateral prefrontal cortex, VFC ventrolateral prefrontal cortex, MFC medial prefrontal cortex, M1C primary motor (M1) cortex, S1C primary somatosensory (S1) cortex, IPC posterior inferior parietal cortex, A1C primary auditory (A1) cortex, STC superior temporal cortex, ITC inferior temporal cortex, V1C primary visual (V1) cortex. Note: all results show only results of significant enrichment.

Back to article page