Fig. 3: CNR2 expression and regulation in human PBMCs.
From: Selective alterations of endocannabinoid system genes expression in obsessive compulsive disorder
a Schematic representation of human CNR2 gene. ATG is the translation start site: filled boxes represent the exons’ translated sequence. In the lower part is shown the CpG island with their sequences and the position of the CpG sites under study. In the upper part are shown the location of primers used for mRNA quantification. b CNR2 relative gene expression in human PBMCs from patients diagnosed with OCD and healthy subjects (CTRL). Scattered plots represent individuals’ mRNA abundance calculated by the Delta-Delta Ct (ΔΔCt) method. *p < 0.05 Mann–Whitney test. c % of DNA methylation represented as scattered dot plots for the individual CpG sites under study as well as for the average (Ave) of the 5 CpG sites under study. Values are reported in Supplementary Table 9.
