Fig. 4: Chronic alcohol self-administration increases PNN densities throughout the hippocampus of rhesus monkeys.
From: Extracellular matrix abnormalities in the hippocampus of subjects with substance use disorder
DG GCL granule cell layer of the dentate gyrus, SLM stratum lacunosum moleculare, SGZ subgranular zone, CA cornu ammonis, SO stratum oriens, SP stratum pyramidale. A Representative microscopy of PNNs labeled with WFA in CA1 SO, scalebar = 50 µm. B Inset of Fig. 4A at high-magnification, scalebar = 30 µm. C Representative microscopy of a WFA-labeled glial cell proximal to the DG GCL, scalebar = 50 µm. D Inset of C at ×40 magnification, scalebar = 50 µm. E Comparisons of PNN densities throughout the hippocampus between control (white bars) and monkeys with chronic alcohol self-administration (red bars). F Comparison of WFA-glia densities in the DG GCL and DG SLM between control and monkeys with chronic alcohol self-administration. G Comparison of WFA-glia densities in the SGZ and CA nuclei of the hippocampus between control and monkeys with chronic alcohol self-administration.
