Fig. 2: Manhattan plot of epigenetic loci associated with 2 year attention problems. | Translational Psychiatry

Fig. 2: Manhattan plot of epigenetic loci associated with 2 year attention problems.

From: Epigenome-wide association study identifies neonatal DNA methylation associated with two-year attention problems in children born very preterm

Fig. 2

Significant associations (FDR < 5%) are shown above the blue solid line (p < 3.5E-5). Bonferroni-significant CpG sites are shown above the red dashed line (p < 1.1E-7) and annotated in black. Highlighted in blue (with ◊) is one significant CpG site (FDR < 5%) located in a gene whose methylation has previously been shown to be associated with ADHD in a prior EWAS (TP73). Highlighted in purple (with Δ) are 4 significant CpG sites (FDR < 5%) located in genes that have been shown to be associated with ADHD in prior GWAS studies (FGFR1, NFIA, PITPNIM3, PIK3R2). Three CpG sites, highlighted in red (with °), are located in genes we previously found to be associated with prenatal risk in this sample (POR; MIR4651; COG4; LPAR5). *Denotes CpG located in co-methylated region (CMR).

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