Table 2 Epigenome-wide association study results for statistically significant CpG sites (FDR < 5%).

From: Epigenome-wide association study identifies neonatal DNA methylation associated with two-year attention problems in children born very preterm

CpG / CMR

Location

Gene annotation

Coefficient

Std Error

p value (raw)

p value (FDR)

Brain-buccal correlation

cg06913365

chr1: 13825255

LRRC38 (Body)

−2.66

0.54

7.99E-07

0.024

0.09

cg08220278

chr1: 180137345

QSOX1 (Body)

−1.55

0.31

3.98E-07

0.020

0.19

cg22727761

chr1: 24286270

PNRC2 (TSS200)

−2.12

0.41

2.61E-07

0.020

0.22

cg19418235+

chr1: 3614558

TP73 (TSS200; Body)

−1.57

0.32

1.21E-06

0.025

0.23

cg09062708

chr1: 61649907-61649973

NFIA (Body)

−1.50

0.31

9.33E-07

0.024

−0.02

cg03355952

chr2: 179316072

PRKRA (TSS1500; TSS200); DFNB59 (TSS200); MIR548N (Body)

−1.81

0.38

1.51E-06

0.026

0.15

cg09560533+

chr2: 241776193

 

1.59

0.32

9.31E-07

0.024

−0.25

cg02843332

chr2: 3283237

TSSC1 (Body)

1.43

0.30

2.44E-06

0.036

0.16

cg08976687

chr2: 85515537

TCF7L1 (Body)

−1.68

0.35

1.34E-06

0.025

0.02

cg01807408

chr3: 87137933

 

2.18

0.44

5.69E-07

0.024

−0.32

cg21415305

chr3: 9851855-9851862

TTLL3 (TSS200)

−1.81

0.31

9.66E-09

0.002

0.39

cg01132150

chr5: 131782489

C5orf56 (Body)

−1.98

0.34

4.26E-09

0.002

−0.15

cg01277890

chr5: 138731822

LOC389333 (TSS1500)

−2.29

0.46

6.24E-07

0.024

0.40

cg25109393

chr5: 73936428-73936437

ENC1 (1stExon; 5’UTR)

−2.08

0.40

2.91E-07

0.020

0.45*

cg05182265

chr7: 156933206

UBE3C (Body)

−2.97

0.59

3.72E-07

0.020

0.86**

cg18773807

chr7: 75543705

POR (TSS1500); MIR4651 (TSS1500)

−2.42

0.48

3.86E-07

0.020

0.13

cg10020385

chr8: 145159706

MAF1 (1stExon; 5’UTR); SHARPIN (TSS1500)

−3.20

0.68

2.20E-06

0.033

0.70**

cg26385256+

chr8: 38326334

FGFR1 (5’UTR; 1stExon)

−1.89

0.40

2.12E-06

0.033

0.10

cg09297702

chr11: 128784689

KCNJ5 (Body)

−1.83

0.32

1.85E-08

0.003

0.11

cg13717333+

chr12: 122459966

BCL7A (1stExon; 5’UTR)

−2.10

0.44

1.57E-06

0.026

0.23

cg26076948+

chr12: 132892417

GALNT9 (Body)

1.70

0.34

6.15E-07

0.024

−0.23

cg02134355

chr12: 53675972

ESPL1 (Body)

1.62

0.35

2.65E-06

0.037

0.11

cg10457436

chr12: 6745871

LPAR5 (TSS1500)

−1.74

0.36

9.54E-07

0.024

0.16

cg11932091

chr12: 8717391-8717487

 

−2.40

0.49

1.07E-06

0.024

0.15

cg12228863

chr13: 95069222

 

2.44

0.50

8.30E-07

0.024

0.04

cg04999580

chr16: 3551846

CLUAP1 (Body)

−2.31

0.48

1.39E-06

0.025

0.24

cg04468927

chr16: 70514664-70514920

COG4 (3’UTR)

−1.59

0.33

1.41E-06

0.025

0.05

cg20139664

chr17: 36628961

ARHGAP23 (Body)

−1.73

0.33

1.66E-07

0.019

0.07

cg11237284

chr17: 6458238

PITPNM3 (Body)

−1.67

0.34

9.88E-07

0.024

0.14

cg22514284

chr17: 72754345

SLC9A3R1 (Body)

−1.44

0.29

1.05E-06

0.024

0.03

cg27648858

chr19: 18266834

PIK3R2 (Body)

−1.46

0.31

1.91E-06

0.031

−0.29

cg14798653

chr19: 6475497

DENND1C (Body)

−1.33

0.28

3.24E-06

0.044

−0.14

cg05076365

chr21: 17011727

 

−1.76

0.36

1.14E-06

0.025

−0.06

  1. Note. The coefficient represents the expected increase or decrease in CBCL T-scores associated with an increase of DNAm from the 25th to 75th percentile. CpGs listed with a range of genomic position are located in co-methylated regions (CMRs). *p < 0.05, **p < 0.01. +Denotes CpGs that were no longer significantly associated with CBCL T-scores after adjustment for familial confounding.
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