Table 3 CpGs associated with child attention problems (FDR < 5%) are linked to genes, exposures, and outcomes in the GWAS and EWAS Catalog.

cg06913365

chr1: 13825255

LRRC38

6

Blood pressure

1

Incident Type 2 Diabetes

cg08220278

chr1: 180137345

QSOX1

15

Blood pressure, anorexia nervosa

—

cg22727761

chr1: 24286270

PNRC2

—

1

HIV infection

cg19418235

chr1: 3614558

TP73

11

Leukemia, visceral adipose tissue measurement, waist-hip ratio, lung carcinoma

—

cg09062708

chr1: 61649907

NFIA

274

Bipolar disorder, risk-taking behavior, educational attainment, brain measurement, mathematical ability, ADHD, substance abuse, antisocial behavior, autism spectrum disorder, anxiety, preterm birth

9

Tissue, GA, Age, Rheumatoid arthritis, Alzheimer’s disease break stage

cg03355952

chr2: 179316072

PRKRA

6

High density lipoprotein cholesterol measurement, atopic eczema, psoriasis

—

DFNB59

—

MIR548N

—

cg09560533

chr2: 241776193

—

—

1

Tissue

cg02843332

chr2: 3283237

TSSC1

—

—

cg08976687

chr2: 85515537

TCF7L1

51

Blood pressure, cervical carcinoma

4

Tissue, age

cg01807408

chr3: 87137933

—

3

Tissue, age, sex

cg21415305

chr3: 9851855

TTLL3

3

Educational attainment

3

Schizophrenia, Progressive supranuclear palsy

cg01132150

chr5: 131782489

C5orf56

—

7

Tissue, GA, Age

cg01277890

chr5: 138731822

LOC389333

—

4

Tissue, age, incident COPD, lung cancer

cg25109393

chr5: 73936428

ENC1

4

Aging, cognition

2

Tissue, HIV infection

cg05182265

chr7: 156933206

UBE3C

35

Type 2 diabetes mellitus, whole brain volume, response to antidepressant, body mass index, systolic blood pressure

6

Tissue, age, GA, maternal smoking in pregnancy

cg18773807

chr7: 75543705

POR

54

Body height, mathematical ability, non-high-density lipoprotein cholesterol measurement

1

Protein levels

MIR4651

—

cg10020385

chr8: 145159706

MAF1

2

Mean corpuscular hemoglobin concentration

1

Atopy

SHARPIN

12

Asthma, hippocampal volume, cortical thickness, Alzheimer’s disease

cg26385256

chr8: 38326334

FGFR1

66

Body mass index, schizophrenia, cortical thickness, autism spectrum disorder, bipolar disorder, ADHD, response to cognitive behavioral therapy, type 2 diabetes mellitus, birth weight, brain measurement, antisocial behavior, substance abuse

5

Age, pancreatic ductal adenocarcinoma, rheumatoid arthritis

cg09297702

chr11: 128784689

KCNJ5

37

Blood pressure, resting heart rate

—

cg13717333

chr12: 122459966

BCL7A

37

Body mass index, body weight, educational attainment

2

Age, Tissue

cg26076948

chr12: 132892417

GALNT9

24

Body mass index, antisaccade response, cardiovascular disease, alcohol consumption

2

Age

cg02134355

chr12: 53675972

ESPL1

7

Body mass index

—

cg10457436

chr12: 6745871

LPAR5

17

High density lipoprotein cholesterol measurement

5

Tissue, age, GA, birthweight

cg11932091

chr12: 8717391

—

—

4

Age, tissue, GA

cg12228863

chr13: 95069222

—

—

—

cg04999580

chr16: 3551846

CLUAP1

20

Body mass index, educational attainment, type 2 diabetes mellitus, cardiovascular disease

—

cg04468927

chr16: 70514664

COG4

6

Body mass index, body weight

2

Tissue, GA

cg20139664

chr17: 36628961

ARHGAP23

16

Reaction time, brain measurement

—

cg11237284

chr17: 6458238

PITPNM3

17

Blood pressure, educational attainment, reaction time, ADHD, substance abuse, antisocial behavior

1

Protein levels

cg22514284

chr17: 72754345

SLC9A3R1

25

White blood cell count

—

cg27648858

chr19: 18266834

PIK3R2

12

Intelligence, ADHD, autism spectrum disorder

7

Tissue, clear cell renal carcinoma, GA, age, hypertensive disorders of pregnancy

cg14798653

chr19: 6475497

DENND1C

3

Brain measurement

5

Tissue, clear cell carcinoma, age, Alzheimer’s disease braak stage, Braak stage

cg05076365

chr21: 17011727

—

—

1

Incident liver cirrhosis