Table 3 Linear regression model for the cross-sectional relationship of depressive symptoms and/or antidepressant use as a predictor of white blood cell count at enrollment (n = 125,307).

From: Depressive symptoms and antidepressant use in relation to white blood cell count among postmenopausal women from the Women’s Health Initiative

  

WBC count (Kcell/ml)

 

Unadjusted

Adjusteda

N

β (95% CI)

β (95% CI)

Model I:

Yes

No

  

Depressive symptoms (Yes vs. No)

13,358

111,949

0.30 (0.12, 0.48)

0.11 (−0.07, 0.29)

Model II:

Yes

No

  

Antidepressant use (Yes vs. No)

8362

116,945

0.34 (0.12, 0.57)

0.11 (−0.11, 0.33)

Model III:

Yes

No

  

Depressive symptoms and/or antidepressant use (Yes vs. No)

19,354

105,953

  

Model IV:

 

0.36 (0.21, 0.51)

0.15 (0.00, 0.31)

Depressive symptoms /Antidepressant use (categorical)

 No depressive symptoms/No antidepressant useb

105,953

Ref.

Ref.

 Depressive symptoms/No antidepressant use

10,992

0.34 (0.15, 0.54)

0.17 (−0.026, 0.37)

 No depressive symptoms/Antidepressant use

5996

0.43 (0.17, 0.69)

0.22 (−0.04, 0.49)

 Depressive symptoms/Antidepressant use

2366

0.24 (−0.16, 0.65)

−0.09 (−0.51, 0.31)

  1. β Slope, CI Confidence Interval.
  2. aAdjusted for WHI component (WHI-CT, WHI-OS), socio-demographic characteristics (age [in years], race [American Indian/Alaska Native, Asian, Native Hawaiian/Other Pacific Islanders, Black, White, More than one race, Unknown/Not reported], ethnicity [Hispanic, non-Hispanic, Unknown/Not reported], education [less than high school, high school, some college, completed college or higher level], household income [<$20,000, $20,000–$49,999, $50,000–$99,999, ≥$100,000], marital status [Married/Partnered, Single, Divorced, Widowed]), lifestyle characteristics (smoking status [Never Smoker, Past Smoker, Current Smoker], alcohol consumption [Non-Drinker, Former Drinker, <1 drink/week, ≥1 drink/week], physical activity [Metabolic equivalent-hours/week]), and health characteristics, namely, body mass index (BMI) [<25, 25– < 30, ≥30 kg/m2], comorbid conditions (cardiovascular disease [Yes, No], hypertension [Yes, No], hyperlipidemia [Yes, No], diabetes [Yes, No]) and self-rated health [Excellent/Very Good/Good, Fair/Poor]).
  3. bReferent category.
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