Table 4 Logistic regression models for the cross-sectional relationship of white blood cell count quartiles as predictors of depressive symptoms and/or antidepressant use at enrollment (n = 125,307)^a.

	N		Unadjusted	Adjusted^b
			OR (95% CI)	OR (95% CI)
Model I – Depressive symptoms (Yes vs. No):	Yes	No
WBC count (Kcell/ml):
1^st quartile	2762	27,365	Ref.	Ref.
2^nd quartile	3183	28,518	1.11 (1.05, 1.17)	1.06 (1.01, 1.13)
3^rd quartile	3386	28,369	1.18 (1.12, 1.25)	1.06 (1.00, 1.12)
4^th quartile	4027	27,697	1.44 (1.37, 1.52)	1.10 (1.05, 1.17)
Model II – Antidepressant use (Yes vs. No):	Yes	No
WBC count (Kcell/ml):
1^st quartile	1709	28,418	Ref.	Ref.
2^nd quartile	1912	29,789	1.07 (0.99, 1.14)	0.97 (0.91, 1.04)
3^rd quartile	2119	29,636	1.19 (1.11, 1.27)	0.99 (0.93, 1.06)
4^th quartile	2622	29,102	1.49 (1.41, 1.59)	1.07 (1.00, 1.15)
Model III – Depressive symptoms and/or antidepressant use (Yes vs. No):	Yes	No
WBC count (Kcell/ml):
1^st quartile	4002	26,125	Ref.	Ref.
2^nd quartile	4592	27,109	1.11 (1.05, 1.16)	1.04 (0.99, 1.09)
3^rd quartile	4902	26,853	1.19 (1.14, 1.24)	1.04 (0.99, 1.09)
4^th quartile	5858	25,866	1.48 (1.42, 1.54)	1.10 (1.06, 1.16)

CI Confidence Interval, OR Odds Ratio, WBC White blood cells.
^aWBC count were defined in quartiles (1^st quartile: <4.8 Kcell/ml, 2^nd quartile: 4.8– < 5.7 Kcell/ml, 3^rd quartile: 5.7– < 6.8 Kcell/ml, 4^th quartile: ≥6.8 Kcell/ml).
^bAdjusted for WHI component (WHI-CT, WHI-OS), socio-demographic characteristics (age [in years], race [American Indian/Alaska Native, Asian, Native Hawaiian/Other Pacific Islanders, Black, White, More than one race, Unknown/Not reported], ethnicity [Hispanic, non-Hispanic, Unknown/Not reported], education [less than high school, high school, some college, completed college or higher level], household income [<$20,000, $20,000–$49,999, $50,000–$99,999, ≥$100,000], marital status [Married/Partnered, Single, Divorced, Widowed]), lifestyle characteristics (smoking status [Never Smoker, Past Smoker, Current Smoker], alcohol consumption [Non-Drinker, Former Drinker, <1 drink/week, ≥1 drink/week], physical activity [Metabolic equivalent-hours/week]), and health characteristics, namely, body mass index (BMI) [<25, 25– < 30, ≥30 kg/m²], comorbid conditions (cardiovascular disease [Yes, No], hypertension [Yes, No], hyperlipidemia [Yes, No], diabetes [Yes, No]) and self-rated health [Excellent/Very Good/Good, Fair/Poor]).

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