Table 5 Linear regression models for change in WBC count between enrollment and 3-year follow-up visits in relation to patterns of depressive symptoms and antidepressant use between enrollment and 3-year follow-up visits.

	WBC count (Kcell/ml)
	β (95% CI)
	N	Unadjusted	Adjusted^a
Depressive symptoms (n = 56,411):
Consistently had no depressive symptoms	47,774	Ref.	Ref.
Depressive symptoms at enrollment only	3453	0.16 (−0.30, 0.62)	0.18 (−0.29, 0.64)
Depressive symptoms at follow-up only	3069	−0.15 (−0.63, 0.33)	−0.14 (−0.64, 0.35)
Consistently had depressive symptoms	2115	−0.74 (−1.32, −0.16)	−0.73 (−1.33, −0.14)
Antidepressant use (n = 58,024):
Consistent non-user (enrollment and follow-up)	52,168	Ref.	Ref.
Enrollment user only	2596	−0.26 (−0.79, 0.26)	−0.25 (−0.78, 0.28)
Follow-up user only	1344	0.13 (−0.59, 0.86)	0.17 (−0.56, 0.90)
Consistent user (enrollment and follow-up)	1916	0.12 (−0.48, 0.74)	0.16 (−0.46, 0.77)

β Slope, CI confidence intervals, WBC White blood cells.
^aAdjusted for WHI component (WHI-CT, WHI-OS), socio-demographic characteristics (age [in years], race [American Indian/Alaska Native, Asian, Native Hawaiian/Other Pacific Islanders, Black, White, More than one race, Unknown/Not reported], ethnicity [Hispanic, non-Hispanic, Unknown/Not reported], education [less than high school, high school, some college, completed college or higher level], household income [< $20,000, $20,000-$49,999, $50,000-$99,999, ≥$100,000], marital status [Married/Partnered, Single, Divorced, Widowed]), lifestyle characteristics (smoking status [Never Smoker, Past Smoker, Current Smoker], alcohol consumption [Non-Drinker, Former Drinker, < 1 drink/week, ≥ 1 drink/week], physical activity [Metabolic equivalent-hours/week]), and health characteristics, namely, body mass index (BMI) [< 25, 25- < 30, ≥ 30 kg/m²], comorbid conditions (cardiovascular disease [Yes, No], hypertension [Yes, No], hyperlipidemia [Yes, No], diabetes [Yes, No]) and self-rated health [Excellent/Very Good/Good, Fair/Poor]).

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