Fig. 1: Effects of alcohol craving on gene expression profiles in AUD patients. | Translational Psychiatry

Fig. 1: Effects of alcohol craving on gene expression profiles in AUD patients.

From: Molecular mechanisms involved in alcohol craving, IRF3, and endoplasmic reticulum stress: a multi-omics study

Fig. 1

A Principal components analysis (PCA) of gene expression profiles in PBMCs obtained at baseline from AUD patients with extreme values for baseline PACS scores. Specifically, six subjects with an average baseline PACS score of 0 (low), and six subjects with an average baseline PACS score of 30 (high) were selected for PBMC RNA-seq. B A heatmap plot showing expression profiles for the most DEGs between high craving and low craving intensity groups based on the PBMC RNA-seq data (FDR < 0.05). C Pathway analysis of the PBMC RNA-seq data was performed using gene set enrichment analysis (GSEA) software [35, 36]. NES is the normalized enrichment score to account for the size of each gene set.

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